Abstract: Through the investigation and analysis of the growth,survival rate,and the activities of digestive enzyme,nonspecific immunity enzyme,metabolic enzyme,and antioxidant enzyme of young fish Coilia nasus,which were fed with compound feed and live feed for 178 days,the effects of compound feed and live feed on growth,survival,and some enzyme activities of young fish C.nasus were studied.The results show that the final body length,final body weight,survival rate,condition factor,and hepato somatic index of compound feed group(125.17 mm,6.27 g,65.73%,0.31 g/cm³,and 1.4%,respectively)were significantly lower than those of live feed group(150.66 mm,12.39 g,85.59%,0.36 g/cm³,and 1.9%,respectively),while there was no significant difference between the two groups in the ratio of intestine length to body length(25.3% and 23.6%,respectively);No protease was detected in livers of two groups,pyloric caecum alkaline protease activity of compound feed group(43.49 U/mg prot)was significantly lower than those of live feed group(86.37 U/mg prot),while there was no significant difference between the two groups in activities of stomach acid protease and intestine alkaline protease;Amylase activities in intestine and pyloric caecum of compound feed group(196.63 and 575.93 U/g prot,respectively)were significantly lower than that of live feed group(928.91 and 1 755.90 U/g prot,respectively),while there was no significant difference between the two groups in amylase activities in liver and stomach;No lipase was detected in livers and stomachs from compound feed group and live feed group,intestine lipase activity of compound feed group(23.55 U/g prot)was significantly higher than that of live feed group(14.39 U/g prot),while there was no significant difference between the two groups in lipase activity of pyloric caecum(17.90 and 13.23 U/g prot,respectively);Alkaline phosphatase(AKP)activity in liver of compound feed group(103.44 U/g prot)was significantly higher than that of live feed group(58.20 U/g prot),while glutamic oxalacetic transaminase(AST/GOT)in liver of compound feed group(20.38 U/g prot)was significantly lower than that of live feed group(32.51 U/g prot).In addition,there was no significant difference between the two groups in activities of acid phosphatase(ACP),glutamic-pyruvic transaminase(ALT/GPT),superoxide dismutase(SOD),glutathione peroxidase(GSH-PX),and catalase(CAT)in liver,and activities of glutamic-pyruvic transaminase(ALT/GPT),glutamic oxalacetic transaminase(AST/GOT),superoxide dismutase(SOD),and glutathione peroxidase(GSH-PX)in serum.The results suggest that C.nasus could ingest the compound feed,there was no significant difference between compound feed group and live feed group in most of digestive enzyme,nonspecific immunity enzyme,metabolic enzyme,and antioxidant enzyme activities,while the growth and survival rates of compound feed group were significantly lower than those of live feed group.Therefore,in order to gradually replace live feed,optimized compound feed formula and improved compound feed that are suitable for C.nasus are recommended.